Investigating the spatial characteristics of the crossmodal interaction between nociception and vision using gaze direction

The present study investigated the influence of nociceptive stimuli on visual stimuli processing according to the relative spatial congruence between the two stimuli of different sensory modalities. Participants performed temporal order judgments on pairs of visual stimuli, one presented near the hand on which nociceptive stimuli were occasionally applied, the other one either to its left or to its right. The visual hemifield in which the stimulated hand and the near visual stimulus appeared was manipulated by changing gaze direction. The stimulated hemibody and the stimulated visual hemifield were therefore either congruent or incongruent, in terms of anatomical locations. Despite the changes in anatomical congruence, judgments were always biased in favor of the visual stimuli presented near the stimulated hand. This indicates that nociceptive-visual interaction may rely on a realignment of the respective initial anatomical representations of the somatic and retinotopic spaces toward an integrated, multimodal representation of external space.