کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
731573 | 893074 | 2010 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Generation of spatio-temporal concentration profiles for cell culture systems: A case study in ammonia Generation of spatio-temporal concentration profiles for cell culture systems: A case study in ammonia](/preview/png/731573.png)
Cellular behavior is influenced by micro-concentration gradients existing in their immediate spatio-environment. A practical real-time measurement system, composed of miniaturized long-lasting sensors placed within a two-dimensional bioreactor and a 32-channel data acquisition system for ammonia, is presented in this paper aiming to generate the spatio-temporal ammonia concentration profiles for the whole culture process. Our results demonstrate the feasibility of the system and its applicability in elucidating the cell growth micro-environment within a bioreactor, which can potentially facilitate the intelligent control of ammonia levels in cell culture systems. The presented system is flexible enough to interface other sensors for generating their spatio-temporal profiles of the sensed cell culture parameters.
Journal: Measurement - Volume 43, Issue 9, November 2010, Pages 1207–1216