کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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740852 | 894191 | 2011 | 6 صفحه PDF | دانلود رایگان |
We report two fluorescent Zn2+ sensors, AD1 and AD2. In aqueous solution, upon addition of Zn2+, AD1 only showed the enhancement on the fluorescence intensity, while AD2, acting as a ratiometric sensor, demonstrated the variations not only on the fluorescence intensity but also on the emission wavelengths. Both sensors exhibit high sensitivity (nM level) and selectivity for Zn2+ over Na+, K+, Mg2+, and Ca2+ at the millimolar level. Moreover, AD2 undergoes significant increase of the TPA cross sections (δmax) at 840 nm by the Zn2+-coordination induced ICT enhancement. The laser scanning confocal microscopy experiments revealed that AD2 is cell-permeable and can indeed visualize the changes of intracellular Zn2+ in living cells through a ratiometric approach by utilizing two-photon excitation.
Journal: Sensors and Actuators B: Chemical - Volume 156, Issue 1, 10 August 2011, Pages 410–415