کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
742212 | 1462110 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Temperature-modulated differential scanning calorimetry in a MEMS device
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
We present a MEMS-based approach to temperature-modulated differential scanning calorimetry (AC-DSC) for biomolecular characterization. Based on a MEMS device integrating microfluidic handling with highly sensitive thermoelectric detection as well as on-chip AC heating and temperature sensing, we perform, for the first time, MEMS-based AC-DSC detection of liquid biological samples, demonstrated by the measurements of protein unfolding. The specific heat capacity and the melting temperature of the protein during the unfolding process are obtained and found to be consistent with published data. This MEMS AC-DSC approach has potential applications to label-free characterization of biomolecules.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 180, April 2013, Pages 60–65
Journal: Sensors and Actuators B: Chemical - Volume 180, April 2013, Pages 60–65
نویسندگان
Bin Wang, Qiao Lin,