کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
743149 | 894343 | 2009 | 7 صفحه PDF | دانلود رایگان |
In this paper a highly sensitive glucose biosensor is proposed based on a polysilicon (poly-Si) wire structure coated with 3-aminopropyltriethoxysilane (γ-APTES) mixed with polydimethylsiloxane-treated hydrophobic fumed silica nanoparticles (NPs) as the sensing membrane. The γ-APTES and fumed silica NPs mixture was directly transferred to and coated onto the poly-Si wire region with the help of a focus-ion-beam (FIB) processed capillary atomic-force-microscope (C-AFM) tip. After the necessary curing and UV illumination processes, the resultant sensor showed an extremely wide linear detection range from 0.1 μM to 10 mM with a channel current sensitivity as high as 5.33 A mM−1 cm−2 (or a channel conductance sensitivity of 70 μS mM−1), and a detection limit as low as 10 nM can be achieved. Our experimental results showed that the poly-Si wire sensor has good selective analysis and operational stability on glucose detection under a 10:1 concentration ratio of glucose and uric acid. Its linear range and lowest detection limit remain virtually unimpaired in the presence of uric acid.
Journal: Sensors and Actuators B: Chemical - Volume 142, Issue 1, 12 October 2009, Pages 273–279