کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7501445 1485961 2018 59 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An alcohol withdrawal test battery measuring multiple behavioral symptoms in mice
ترجمه فارسی عنوان
باتری تست الکتریکی با اندازه گیری علائم رفتاری متعدد در موش
کلمات کلیدی
سندرم ترک سیگار، حوزه های رفتاری، ماوس، باتری تست کنید
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Withdrawal symptoms were assessed using commonly used tests after administration of ethanol in vapor for 72 continuous hours. We found significant effects of ethanol withdrawal versus air-breathing controls on nearly all symptoms, spanning 4 days following ethanol vapor inhalation. Withdrawal produced hypothermia, greater neurohyperexcitability (seizures and tremor), anxiety-like behaviors using an apparatus (such as reduced transitions between light and dark compartments), anhedonia (reduced sucrose preference), Straub tail, backward walking, and reductions in activity; however, there were no changes in thermal pain sensitivity, hyper-reactivity to handling, or anxiety-like emergence behaviors in other apparatus. Using these data, we constructed a refined battery of withdrawal tests. Individual differences in severity of withdrawal among different tests were weakly correlated at best. This battery should be useful for identifying genetic influences on particular withdrawal behaviors, which should reflect the influences of different constellations of genes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alcohol - Volume 68, May 2018, Pages 19-35
نویسندگان
, , , , , , ,