Assessment of the gas phase stability of quadruplex DNA using travelling wave ion mobility mass spectrometry

▶ ESI-TWIMS enabled distinction of ions of the same m/z that corresponded to folded and unfolded qDNA. ▶ ESI-TWIMS supported that ions carrying 4 and 5 negative charges arose from folded intramolecular qDNA. ▶ This work shows the utility of ESI-TWIMS in distinguishing among different conformations and structures of qDNA.