کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7640567 | 1494855 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exploiting CdSe/ZnS core-shell photocatalyst modified with cytochrome c for epinephrine determination in drugs utilized in cardiopulmonary resuscitation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This work presents the development and application of a biosensor based on cadmium selenide/zinc sulphide core-shell quantum dot modified with the redox protein cytochrome c (CdSe/ZnS-Cytc) for the photoelectrochemical determination of epinephrine (EP). The photoactive biocomposite was immobilized on the surface of a glass substrate modified with indium doped tin oxide (CdSe/ZnS-Cytc/ITO). The photoactive film was characterized by electrochemical impedance spectroscopy and the photocurrent measurements were obtained by chronoamperometry using a LED light lamp as source of irradiation. After the experimental parameters optimization, the biosensor presented a good response for EP oxidation in a wide linear concentration range between 1 μmol Lâ1 and 1.2 mmol Lâ1 (with r = 0.999; n = 9). A detection limit of 2 nmol Lâ1 was obtained. The selectivity of the photosensor was evaluated against species such as uric acid, ascorbic acid, folic acid, barbital, glucose, and urea, and the results showed that the proposed biosensor has a good selectivity for the detection of EP. The CdSe/ZnS-Cytc/ITO photoelectrochemical biosensor was applied in injectable drug samples used in cardiopulmonary resuscitation. The recovery tests in the samples showed recovery values between 101 and 110% suggesting a good accuracy for the proposed method.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microchemical Journal - Volume 139, June 2018, Pages 18-23
Journal: Microchemical Journal - Volume 139, June 2018, Pages 18-23
نویسندگان
André Silva Freires, Fernanda Maria dos Reis Lima, Sakae Yotsumoto-Neto, Saimon Moraes Silva, Flávio Santos Damos, Rita de Cássia Silva Luz,