کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7641341 1494864 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determination of parabens in domestic sewage by isotope-coded derivatization coupled with high performance liquid chromatography-tandem mass spectrometry
ترجمه فارسی عنوان
تعیین پارابنها در فاضلاب داخلی با استفاده از مشتق سازی ایزوتوپ همراه با طیف سنجی جرم کروماتوگرافی مایع با عملکرد بالا
کلمات کلیدی
واکنش مشتق شده از ایزوتوپ کدگذاری، پارابنز، کروماتوگرافی مایع با کارایی بالا، طیف سنجی جرمی،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
We have established an isotope labeling protocol for determining parabens in wastewater, based on a pair of isotope-coded derivatization reagents, by high performance liquid chromatography (LC) and electrospray mass spectrometry (ESI-MS). The pair of reagents used in our work were d0-10-methylacridone-2-sulfonyl chloride (d0-MASC, light form) and d3-10-methylacridone-2-sulfonyl chloride (d3-MASC, heavy form). d0-MASC and d3-MASC could easily derivatize parabens at 55 °C for 7.5 min in the mixture of bicarbonate and acetonitrile (1:1 v/v). It is shown that the derivatization offers 1-2 orders of magnitude signal enhancement over underivatized counterparts. The global isotope internal standard technology was employed for quantification analysis with d3-MASC-paraben as internal standard for corresponding d0-MASC-paraben. In addition, homologous internal standard was simultaneously used to correct derivatization processes. The obtained double internal standard calibration curves for parabens were linear over the range of 1-500 nmol L− 1 (r > 0.997). The isotope-coded derivatization based quantification method was precise and practical with RSD ≤ 3.6% and accuracy ranged 96.5 to 104.7%. The proposed method has also been successfully applied to the quantification of parabens in domestic sewage samples with precisions ≤ 5.2% and recoveries ≥ 87.9%. Five kinds of paraben including methylparaben, ethylparaben, propylparaben, butylparaben, and benzylparaben were detected in the tested samples. The quantitative results indicated that parabens were at nmol L− 1 level or lower, and ethylparaben were the most abundant, followed by methylparaben, propylparaben and butylparaben. It has been demonstrated that the isotope-coded derivatization reagents are useful for accurate quantification of analytes having target functional groups in real samples.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microchemical Journal - Volume 130, January 2017, Pages 420-427
نویسندگان
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