کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7643028 | 1494877 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protein structure is changed in psoriatic skin on the unaffected region - Imaging possibility with ATR-FTIR spectroscopy
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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![عکس صفحه اول مقاله: Protein structure is changed in psoriatic skin on the unaffected region - Imaging possibility with ATR-FTIR spectroscopy Protein structure is changed in psoriatic skin on the unaffected region - Imaging possibility with ATR-FTIR spectroscopy](/preview/png/7643028.png)
چکیده انگلیسی
Psoriasis is a T lymphocyte-mediated inflammatory disorder that affects the skin. A number of studies have demonstrated the occurrence of lipid alterations in psoriatic skin, resulting in a highly perturbed stratum corneum (SC). Relatively little attention has been paid to the protein conformation of the SC. In this study, the attenuated total reflection Fourier transform infrared (ATR-FTIR) spectrum of the untreated psoriatic patients' unharmed SC was obtained after tape stripping. We focused on the amide-I band components in order to establish whether there are any protein alterations in the intact areas of psoriatic skin. Fourier self-deconvolution (FSD) of the amide-I band was followed by curve-fitting to generate the underlying components. Integration of band areas provided an estimate of the secondary structure. The results indicated decreases in all amide-I band components, the peak at 1660 cmâ 1 revealing the most dramatic change. This peak is characteristic of the turn structure in the protein chain. The decrease is marked in the case of the β-sheet structure at 1630 cmâ 1 too. This ATR-FTIR imaging is a rapid and simple noninvasive method, promotes a better understanding of the disease, and would be helpful in following the treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microchemical Journal - Volume 117, November 2014, Pages 183-186
Journal: Microchemical Journal - Volume 117, November 2014, Pages 183-186
نویسندگان
Boglárka Balázs, Gabriella Farkas, Ottó Berkesi, Rolland Gyulai, Szilvia Berkó, Mária Budai-Szűcs, Piroska Szabó-Révész, Lajos Kemény, Erzsébet Csányi,