Synthesis, insecticidal activities and SAR studies of novel anthranilic diamides containing trifluoroethoxyl substituent and chiral amino acid moieties

Based on the structures of ryanodine receptors (RyRs) activators anthranilic diamide insecticidal agents and FKI-1033, a series of 18 novel trifluoroethoxyl-containing chiral anthranilic diamides Ia-i and IIa-i were synthesized. Their insecticidal activities were evaluated systematically and the SAR was discussed.