Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin

More than 70 diketopiperazine derivatives based on the structure of Barettin have been synthesized and evaluated for the bioactivity against root-knot nematode M. incognita. The most active compound showed a nematicidal activity of 75% at 2.4 μmol/L.