A practical synthesis of trifluoromethyl alkyl ketones

A practical approach to TFMKs under mild conditions by “trifluoroacetic ester/ketone metathesis” was described. The i-Pr and t-Bu alkyl ketones were used to produce TFMKs with high boiling points by distillation or recrystallization. The solvent-free strategy was effective used to collect volatile TFMKs.