Nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls with PhSO2CF2H reagent in the presence of in situ generated substoichiometric amount of base

- The reactions between carbonyls and PhSO2CF2H have been accomplished using in situ generated substoichiometric amount of base.
- A protocol for effective difluoro(phenylsulfonyl)methylation of enolizable aldehydes under basic conditions is developed.
- The reactivity difference between PhSO2CF2H and CF3H toward carbonyls has been disclosed and rationalized.