Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes: In vitro DNA binding, cleavage, and antitumor activities

Four Schiff bases derived from 4-ethyl(methyl)thiosemicarbazone were synthesized, all these ligands were coordinated with molybdenum(II), the molecular structure of the complexes were characterized by X-ray single-crystal structure, the activity of ligands and their respective complexes for DNA binding and cleavage were determined, furthermore the activity of complexes against human colorectal (HCT 116) cell lines were investigated.