Cytotoxic triterpene saponins from the underground parts of six Lysimachia L. species

► Saponins from underground parts of six Lysimachia L. species were investigated. ► Four isolated compounds were reported in genus Lysimachia for the first time. ► Saponins with 13β,28-epoxy-bridge could be a chemotaxonomic marker of Lysimachia. ► Antiproliferative activity against cancer and normal cell lines is discussed.