Mitochondria-targeted platinum(II) complexes induce apoptosis-dependent autophagic cell death mediated by ER-stress in A549 cancer cells

We synthesized two mono-functional platinum complexes, which target the mitochondria and exhibit high cytotoxicity, including in cisplatin-resistant cells. Mon-Pt-2 induced a significant ROS release and ER stress response mediated by mitochondrial dysfunction, ultimately resulting in simultaneous apoptosis and pro-autophagy in A549 cells. Importantly, compared to cisplatin, Mon-Pt-2 exhibits lower toxicity and better anticancer activity in a murine tumor model.320