Synthesis and anticancer activity evaluation of novel azacalix[2]arene[2]pyrimidines

Novel azacalix[2]arene[2]pyrimidines were designed and synthesized. Compound 4j exhibited strong inhibitory activity against MCF7 cells, and its mechanisms were involved in inducing apoptosis via up-regulation of caspase-3 and caspase-9 cell and cycle arrest at the S phase.182