Synthesis and biological evaluation of 4-(2-fluorophenoxy)-3,3′-bipyridine derivatives as potential c-met inhibitors

Six series of novel 4-(2-fluorophenoxy)-3,3′-bipyridine derivatives conjugated with aza-aryl formamide/amine scaffords were synthesized and evaluated for their cytotoxicity and c-Met kinase activity in vitro. Compound 26c was identified as a lead compound for further structural optimization and antitumor activity screening purpose.