Efficient synthesis of new antiproliferative steroidal hybrids using the molecular hybridization approach

Steroidal hybrids were synthesized and evaluated for their antiproliferative activity. Compound 12g potently inhibited growth of SH-SY5Y cells possibly through the inactivation of LSD1, arrested cell cycle at G2/M phase, induced apoptosis and decreased MMP. Docking simulations were performed to rationalize the potency toward LSD1.229