Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII

Two series of amido and ureido-sulfonamides conjugated with isatins were synthesized and evaluated for their inhibitory activity against a panel of hCAs; I, II (cytosolic) and IX, XII (transmembrane).156