Synthesis and biological evaluation of new curcumin analogues as antioxidant and antitumor agents: Molecular modeling study

We synthesized novel curcumin analogues with antioxidant and anticancer activities. Compound 7h showed remarkable activity having 82.60% inhibition of the ABTS radical cation, 100% death of cultured EAC cells and 82% tumor growth inhibition. Also docking studies showed that compound 7h is well fitted in the active site of telomerase enzyme with Gln B367, Lys B169 and Asn B303 aminoacid residues.163