کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7799856 1501119 2015 97 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and synthesis of piperidine derivatives as novel human heat shock protein 70 inhibitors for the treatment of drug-resistant tumors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design and synthesis of piperidine derivatives as novel human heat shock protein 70 inhibitors for the treatment of drug-resistant tumors
چکیده انگلیسی
HSP70 is a potential target for tumor treatments. Herein, novel HSP70 inhibitors, piperidine derivatives, were designed and biologically evaluated. The results show that the HSP70 inhibitors have a good antitumor activity, especially in lapatinib-resistant cancer cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 97, 5 June 2015, Pages 19-31
نویسندگان
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