New diarylamides and diarylureas possessing 8-amino(acetamido)quinoline scaffold: Synthesis, antiproliferative activities against melanoma cell lines, kinase inhibition, and in silico studies

A series of diarylureas and diarylamides possessing 4-aryl-8-amino(acetamido)quinoline scaffold was synthesized. Their in vitro antiproliferative activities against ten melanoma cell lines, MEK/ERK kinase inhibition, and in silico studies are reported.