High antitumor activity of 5,7-dihalo-8-quinolinolato cerium complexes

Three cerium complexes with 5,7-dihalo-8-quinolinoline were synthesized. They exhibited enhanced cytotoxicity and selectivity vs. 5,7-dihalo-8-quinolinoline. Intercalation is the most probable binding mode for both the complexes and quinolinoline to NDA.