18F-Labeled 2-phenylquinoxaline derivatives as potential positron emission tomography probes for in vivo imaging of β-amyloid plaques

► Two novel 18F-labeled 2-phenylquinoxaline derivatives were synthesized. ► Both of them displayed high affinity to Aβ1-42 aggregates. ► They showed excellent plaque labeling on brain sections of AD human and Tg mice. ► [18F]4a showed high initial uptake (8.17% ID/g) and rapid washout from the brain.