Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity

► Novel 4-thiazolidinones were designed according to their binding modes in COX-2. ► The structures of them were confirmed by spectral methods and elemental analysis. ► 3d and 4d having CH3 on the phenyl ring are the most potent and selective compounds.