Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines

► Synthesis of novel 2-amino-substituted-1,3-benzoxazines. ► DNA-PK inhibition data for 2-amino-substituted-1,3-benzoxazines. ► 2-(Pyridin-3-ylmethyl)-1,3-benzoxazines showed significant DNA-PK inhibition. ► PI3K inhibition studies revealed that compound 27 is highly potent. ► Docking and SAR study for some of the 2-morpholino-1,3-benzoxazines.