دانلود مقالات ISI درباره Dna-Pk + ترجمه فارسی

میکروبیوتا به عنوان واسطه پیشرفت و درمان سرطان

Microbiota as a mediator of cancer progression and therapy

Keywords: AOM; azoxymethane; Apc; adenomatous polyposis coli; CAC; colitis associated cancer; CRC; colorectal cancer; DNA-PK; DNA-dependent protein kinase; GF; germ free; GI; gastrointestinal; IBD; inflammatory bowel diseases; IL; interleukin; MAIT; mucosa-associat

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

پیشرفت راهبرد های عصبی زیستی در برابر شکست پروتئازازیس: چالش های ناشی از تولید نانو

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration

Keywords: AAA; ATPases associated with diverse cellular activities; 17-AAG; 17-N-allylamino-17-demethoxygeldanamycin; ABC; ATP-binding cassette; ABCE1; ATP binding cassette subfamily E member 1; AD; Alzheimer's disease; AIF; apoptosis inducing factor; Akt; Alpha se

دانلود رایگان متن کامل مقاله ISI 104 صفحه سال انتشار : 2017 سفارش ترجمه

فعالیت اتصال کروماتوگرافی کوم در طی آپوپتوز زودرس ناشی از داروهای شیمی درمانی

DNA binding activity of Ku during chemotherapeutic agent-induced early apoptosis

Keywords: Apoptosis; Ku protein; DNA-PK;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

وورتمنین اثر ترکیبی این اتوزوئید و سیس پلاتین را در سلول های گلیوما انسان تقویت می کند

Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells

Keywords: ATM; ataxia telangiectasia-mutated kinase; ATR; ataxia telangiectasia and Rad3-related kinase; CI; combination index; CLL; chronic lymphocytic leukemic cells; DNA-PK; DNA-dependent protein kinase; DNA-PKcs; DNA-dependent protein kinase catalytic subunit;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

تشخیص حساسیت به سیستم ایمنی در مقابل رترو ویروس ها: درگیری بین سنسورهای ذاتی و سازنده های میزبان

Unmasking immune sensing of retroviruses: Interplay between innate sensors and host effectors

Keywords: AIM2; absent in melanoma 2; AP-1; activating protein-1; APOBEC; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like; AZT; azidothymidine; CCCR5; C-C chemokine receptor type 5; CDK1; cyclin-dependent kinase 1; CXCR4; C-X-C chemokine receptor t

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

پیوستن به انتهای غیرخطی: راه حل خوبی برای پایان دادن به بد است

Nonhomologous end joining: A good solution for bad ends

Keywords: Alt-EJ; alternative end joining; APLF; aprataxin and polynucleotide kinase/phosphatase-like factor; ATM; ataxia-telangiectasia mutated; ATR; ATM-, Rad3-related; APTX; aprataxin; β-Casp; metallo-β-lactamase-associated CPSF Artemis SNM1 PSO2; BER; base ex

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

DNA repair inhibitors as radiosensitizers in human lung cells

Keywords: DNA repair; DNA-PK; ATM; ATR; Inhibition; Ionizing radiation; Lung cancer;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

DNA damage, metabolism and aging in pro-inflammatory T cells

Keywords: EC; endothelial cell; ROS; reactive oxygen species; ATP; adenosine 5′-triphosphate; ER; endoplasmic reticulum; mtDNA; mitochondrial DNA; ETC; electron transport chain; mROS; mitochondrial ROS; NADPH; nicotinamide adenine dinucleotide phosphate; TNF-α;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Integrating plant and animal biology for the search of novel DNA damage biomarkers

Keywords: ARP; actin related protein; ASK; Arabidopsis SPK1-like; At; Arabidopsis thaliana; ATAF; arabidopsis transcription activation factor; ATM; ataxia telangiectasia mutated; ATR; ATM and Rad3-related; ATRIP; ATR-interacting protein; BARD; BRCA1-associated RING

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

A qPCR assay for measuring the post-integrational DNA repair in HIV-1 replication

Keywords: HIV; Integration; DNA repair; qPCR; DNA-PK; DNA-PKcs;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2018 سفارش ترجمه

Inhibition of Notch1/Hes1 signaling pathway improves radiosensitivity of colorectal cancer cells

Keywords: Notch1; Colorectal cancer; Radiosensitiviy; γ-H2AX; DNA-PK;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[e][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation

Keywords: Synthesis of O-substituted-2-morpholino-8-aryl-benzo-oxazin-4-one; DNA-PK; PI3K; PDE3A; Antiplatelet activity;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

RNA polymerase II pausing and transcriptional regulation of the HSP70 expression

Keywords: HSP; heat shock protein; HSF1; heat shock factor 1; Pol II; RNA polymerase II; UPR; unfolded protein response; HSE; heat shock element; P-TEFb; positive transcription elongation factor b; PARP; poly(ADP)-ribose polymerase; PAF1; polymerase associated fact

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma

Keywords: GBM; glioblastoma; Ape1; apurinic endonuclease 1; DSB; double strand break; BER; base excision repair; siGFP; siRNA against green fluorescent protein; siApe1; siRNA against Ape1; PEI; polyethyleneimine; CTX; chlorotoxin; CP; chitosan-grafted PEG; NP; nano

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases

Keywords: hSSB1; DNA-PK; PPP-family phosphatase; Replication fork; Replication stress;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Radiosensitizing activity of novel small molecule BRCA1 and DNA-PK inhibitors in lung and colon carcinoma

Keywords: Radiosensitizing; DNA-PK; BRCA1; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Protein profiling and angiogenic effect of hypoxia-cultured human umbilical cord blood-derived mesenchymal stem cells in hindlimb ischemia

Keywords: ABL; abelson murine leukemia viral oncogene homolog; BCL-XL; B-cell lymphoma-extra large; Cy; Cyanine; DAVID; Database for annotation visualization and integrated discovery; DNA-PK; DNA-activated protein kinase; 4E-BP1; eukaryotic initiation factor 4E-bin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of kinases phosphorylating 13 sites in the nuclear, DNA-binding protein NUCKS

Keywords: NUCKS; nuclear, ubiquitous, casein kinase and cyclin kinase substrate; NLS; nuclear localization signal; CK2; casein kinase 2; DNA-PK; DNA activated kinase; PIKK; phosphatidylinositol 3-kinase-related kinase; ATM kinase; ataxia telangiectasia mutated kina

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases

Keywords: ALP; alkaline phosphatase; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; BER; base excision repair; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CHIP; carboxyl terminus of Hsp70-interacting protein; CLL; chronic lympho

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs)

Keywords: Ku; DNA-PK; NHEJ; Protein-DNA interaction; Protein-protein interaction;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Autophagy: The spotlight for cellular stress responses

Keywords: HSC70; Heat Shock 70KDa protein; AMPK; AMP-activated protein kinase; ATG; autophagy-related genes; Beclin-1; coiled-coil, myosin-like BCL2-interacting protein; CQ; chloroquine; DNA-PK; DNA-dependent protein kinase; FYVE; Fab1, YOTB, Vac1 and EEA1; GFP; gr

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Maximising the potential of AKT inhibitors as anti-cancer treatments

Keywords: AE; adverse event; CRPC; castrate resistant prostate cancer; DLT; dose limiting toxicity; DNA-PK; DNA-dependent protein kinase; DSB; double strand break; GSK3β; glycogen synthase kinase beta; INPP4B; polyphosphate 4-phosphatase type II; MTD; maximum tole

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells

Keywords: DNA-PK; DNA-PKcs; Osteosarcoma; Radiotherapy; Radiosensitizers; KU60648;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors

Keywords: ATR; ataxia telangiectasia and Rad-3 related protein; PIKK; phosphatidylinositol 3-kinase-related protein kinase; ATM; ataxia telangiectasia mutated; mTOR; mammalian target of Rapamycin; DNA-PK; DNA-dependent protein kinase; 3D; three-dimensional; MCL; ma

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D

Keywords: AIF; apoptosis inducing factor; A-T; ataxia telangiectasia syndrome; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; CGC; cerebellar granule cells; DNA-PK; DNA-dependent protein kinase; Dox; doxorubicin; DSB; doubl

دانلود رایگان متن کامل مقاله ISI 58 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis of linear and angular aryl-morpholino-naphth-oxazines, their DNA-PK, PI3K, PDE3A and antiplatelet activity

Keywords: GMDSCYROVRGFJQ-UHFFFAOYSA-N; ZZFLOLPIYREIJF-UHFFFAOYSA-N; NPAQJVQWPVCAAC-UHFFFAOYSA-N; OEBRAGKQHHRREZ-UHFFFAOYSA-N; GBNVXPBLNBMMGB-UHFFFAOYSA-N; QKAWQVYLNSXWTJ-UHFFFAOYSA-N; AXPCTAGRSPTVNT-UHFFFAOYSA-N; PYSQNWXNMBKCBM-UHFFFAOYSA-N; QIRKIYPHAGOXOX-UHFFFAOY

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Modulation of ionizing radiation-induced effects by NU7441, KU55933 and VE821 in peripheral blood lymphocytes

Keywords: Ionizing radiation; Lymphocytes; KU55933; NU7441; VE821; ATM; ataxia-telangiectasia mutated kinase; ATR; ataxia telangiectasia and Rad3-related protein kinase; DMSO; dimethyl sulfoxide; DNA-PK; DNA-dependent protein kinase; DSB; double strand break; Gy; g

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

The nuclear aryl hydocarbon receptor is involved in regulation of DNA repair and cell survival following treatment with ionizing radiation

Keywords: AhR; γ-H2AX; DNA-PK; Histone modification; DNA repair

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

EBV-LMP1 suppresses the DNA damage response through DNA-PK/AMPK signaling to promote radioresistance in nasopharyngeal carcinoma

Keywords: LMP1; DNA damage response; DNA-PK; AMPK; Nasopharyngeal carcinoma;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

In-silico screening for DNA-dependent protein kinase (DNA-PK) inhibitors: Combined homology modeling, docking, molecular dynamic study followed by biological investigation

Keywords: DNA-PK; Homology modeling; Virtual screening; Molecular dynamic

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Original ArticleInhibition of ATR-dependent feedback activation of Chk1 sensitises cancer cells to Chk1 inhibitor monotherapy

Keywords: Chk1; ATR; ATM; DNA-PK; Kinase inhibitor; Replication stress;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines

Keywords: Suzuki coupling synthesis of 8- and 6-aryl-2-morpholino-1,3-benzoxazines; DNA-PK; PI3K; Anti-cancer activity;

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2016 سفارش ترجمه

TDP-43/FUS in motor neuron disease: Complexity and challenges

Keywords: AD; Alzheimer's disease; Ago2; Argonaute 2; ALS; Amyotrophic lateral sclerosis; ALS/PD; amyotrophic lateral sclerosis and Parkinsonism-dementia complex; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATF3; activating transcription factor 3

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2016 سفارش ترجمه

Cancer TARGETases: DSB repair as a pharmacological target

Keywords: DSB repair; Genome instability; Cancer; Kinases; Helicases; Nucleases; ALT; alternative telomere lengthening; AML; acute myeloid leukemia; A-T; ataxia-telangiectasia; ATM; ataxia-telangiectasia mutated; ATP; adenosine triphosphate; ATR; ataxia-tel

دانلود رایگان متن کامل مقاله ISI 110 صفحه سال انتشار : 2016 سفارش ترجمه

Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase II and activates the ATM kinase to trigger p53-dependent apoptosis

Keywords: ab; antibody; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3 related; DAPI; 4′,6-diamidino-2-phenylindole; DNA-PK; DNA-dependent protein kinase; DOX; doxorubicin; ERK1/2; extracellular signal-regulated kinase 1/2; H2AX; histone

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency

Keywords: DNA double-strand break repair; nonhomologous end-joining; double-strand break repair deficiency; XRCC4/LIG4; immunodeficiency; microcephaly; CID; Combined immunodeficiency; CS; Cockayne syndrome; CSR; Class-switch recombination; DNA-PK; DNA-dependent pro

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy

Keywords: BRCA1; Base excision repair; ATM; DNA-PK; Small molecule inhibitors; Synthetic lethality; Cisplatin; Chemopotentiation;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

The Nuclear Factor κB pathway: A link to the immune system in the radiation response

Keywords: Nuclear Factor κB; Immune system; Cellular radiation response; Linear energy transfer; Bystander effect; Chemokines; A20 (TNFAIP3); tumor necrosis factor inducible protein 3; ARD; ankyrin repeat domain; ATM; ataxia telangiectasia mutated protein; β-TrCP

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis

Keywords: DNA-dependent protein kinase; Non-homologous end joining; Mitosis; ATM; ataxia telangiectasia mutated; ATR; ATM- and Rad3-related; ds; double-stranded; cryo-EM; cryo-electron microscopy; DSB; DNA double strand break; DNA-PK; DNA-activated/dependent protei

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of dual DNA-PK MDR1 inhibitors for the potentiation of cytotoxic drug activity

Keywords: DNA-PK; MDR1; NU7441; Cancer; Multidrug resistance;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers

Keywords: ATM; ATR; DNA-PK; Ovarian cancer; Biomarker

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

The repair of environmentally relevant DNA double strand breaks caused by high linear energy transfer irradiation - No simple task

Keywords: DNA double strand break repair; High-LET radiation; Alpha particles; HZE particles; Non-homologous end-joining; Artemis; DNA-PK; Ku;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Distinct functions of steroidogenic factor-1 (NR5A1) in the nucleus and the centrosome

Keywords: CDK2; cyclin-dependent kinase 2; DNA-PK; DNA-dependent protein kinase; DNA-PKcs; DNA-dependent protein kinase catalytic subunit; SF-1; Steroidogenic Factor 1 NR5A1, Ad4BP; SUMO; small ubiquitin like modifier; MT; microtubule; SF-1; Adrenal; Gonad; Centros

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453

Keywords: PUFA; polyunsaturated fatty acid; RTK; receptor tyrosine kinase; FGFR; fibroblast growth factor receptor; IGFR; insulin-like growth factor receptor; PDK1; phosphoinositide-dependent kinase 1; mTOR; mammalian target of rapamycin; PDGF; platelet-derived gro

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

DNA double‐strand break response in stem cells: Mechanisms to maintain genomic integrity

Keywords: ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; BRCA1; breast cancer type 1 susceptibility protein; CtBP; C-terminal binding protein; CtIP; CTBP interacting protein; DDR; DNA damage response; DNA-PK; DNA-dependent

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells

Keywords: Cathepsin D; Apoptosis; Autophagy; DNA-PK; Oxidative stress

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Transcriptional regulation by post-transcriptional modification-Role of phosphorylation in Sp1 transcriptional activity

Keywords: Akt; protein kinase B; AT1R; angiotensin II type 1 receptor; ATM; ataxia telangiectasia-mutated protein kinase; CDK; cyclin-dependent kinase; CK-II; casein kinase-II; DNA-PK; DNA-dependent protein kinase; EBV; Epstein-Barr virus; EGF; epidermal growth fac

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family

Keywords: DNA-repair inhibitors; Cancer; PIKK family; DNA-PK; ATM; ATR;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Gefitinib Radiosensitizes Stem-Like Glioma Cells: Inhibition of Epidermal Growth Factor Receptor-Akt-DNA-PK Signaling, Accompanied by Inhibition of DNA Double-Strand Break Repair

Keywords: Gefitinib; Radiotherapy; Brain tumor stem cells; DNA-PK; EGFR;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage

Keywords: Ara-C; cytarabine; ATM; ataxiatelangiectasia-mutated; ATR; ATM- and Rad3-related; CAT; catalase; CHK2; the checkpoint kinase 2; CK1; casein kinase 1; DHE; dihydroethidium; DNA-PK; DNA-dependent serine/threonine protein kinase; Grx; glutaredoxin; HAT; hist

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه