Distinct functions of steroidogenic factor-1 (NR5A1) in the nucleus and the centrosome

► SF-1 is dynamically localized to both the nucleus and the centrosome. ► SF-1 moves to different compartments of the nucleus depending on its modification types. ► In the centrosome SF-1 regulates centrosome homeostasis by preventing aberrant DNA-PK activation. ► SF-1 controls cell growth from both the nucleus and the centrosome.