دانلود مقالات ISI درباره Cdk2 + ترجمه فارسی

هورمون تیروئید در تنظیم کارسینوم هپاتوسلولار و محیط میکرو آن

Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment

Keywords: Thyroid hormone; Liver cancer; Tumor microenvironment; Liver fibrogenesis; ALT; alanine amino transferase; BBC; basal cell carcinoma; CCL4; carbontetrachloride; CD; choline-deficient; CDK2; cyclin-dependent kinase; CSC; cancer stem cell; DKK; dickkopf Wnt

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

هیدرولیزهای پروتئین ایمنی و ضدسرطانی (پپتیدها) از پروتئین مواد غذایی: بررسی

Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: A review

Keywords: ACE; angiotensin converting enzyme; AO; acridine orange; BAD; Bcl-2-associated death promoter; BAX; BCL2-associated X protein; B cells; B lymphocytes; Bcl-2; B-cell lymphoma 2; CCL18; chemokine (CC motif) ligand 18; CD; cluster of differentiation; CDK2; c

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

اثر جهش های پپتیدی رهبر بر عملکرد بیولوژیکی ژن میواستات گاو

The effect of leader peptide mutations on the biological function of bovine myostatin gene

Keywords: MSTN; myostatin; GDF-8; growth differentiation factor-8; CDK2; cyclin dependent kinase 2; qPCR; quantitative real-time PCR; FBS; fetal bovine serum; BSA; bovine serum albumin; Myostatin gene; Cattle; Gene optimization; Cell proliferation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

آپوپتین: عوامل ضد سرطان انتخابی

Apoptins: selective anticancer agents

Keywords: anticancer agents; anaphase-promoting complex; CDK2; protein kinase C; protein phosphatase 2A

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

انسداد سلولهای اندوتلیال و بیماری های عروقی مرتبط با سن

Endothelial Cell Senescence and Age-Related Vascular Diseases

Keywords: Endothelial cell senescence; Genetic; Vascular ageing; Age-related diseases; Stem cell; Ang II; angiotensin II; APOE; apolipoprotein E; AQP1; aquaporin 1; ASS1; argininosuccinate synthase 1; CDK2; cyclin-dependent kinase 2; CDKN2A; cyclin-dependent kinase

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

استراتژی های فارماکولوژی سیستم برای کشف دارو و ترکیب آن با برنامه های کاربردی برای بیماری های قلبی عروقی

Systems pharmacology strategies for drug discovery and combination with applications to cardiovascular diseases

Keywords: ADME; Absorption, distribution, metabolism and elimination; CVD; Cardiovascular diseases; TTD; Therapeutic Target Database; DT network; Drug-target network; TT network; Target-target network; DD network; Drug-drug network; OB; Oral bioavailability;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

از پیش سازها به مولکولهای الیگودندروسیتها: نقش عوامل درونی و بیرونی به پویایی ماده سفید در مغز بزرگسالان

From precursors to myelinating oligodendrocytes: Contribution of intrinsic and extrinsic factors to white matter plasticity in the adult brain

Keywords: AKT1; serine-threonine-specific protein kinase AKT-PKB; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; bHLH; basic helix-loop-helix transcription factor; BMP; bone morphogenic protein; BMP2; bone morphogenic protein 2

دانلود رایگان متن کامل مقاله ISI 72 صفحه سال انتشار : 2014 سفارش ترجمه

مکانیسم سمیت مرکزی سمیت سلولی در برابر سلول های آدنوکارسینوم ریه انسان

Mechanism of arctigenin-mediated specific cytotoxicity against human lung adenocarcinoma cell lines

Keywords: ARG; arctigenin; GSH; glutathione; G0/G1; Gap 0/Gap 1; NPAT; nuclear protein of the ataxia telangiectasia locus; CDK2; cyclin-dependent kinase 2; CDK7; cyclin-dependent kinase 7; akt-1; alpha serine/threonine-protein kinase; Arctigenin (ARG); Mechanism; S

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Increased activity of both CDK1 and CDK2 is necessary for the combinatorial activity of WEE1 inhibition and cytarabine

Keywords: WEE1; AZD1775; Cytarabine; Leukemia; CDK1; CDK2; DNA damage; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2018 سفارش ترجمه

Analysis of CDK2 mutations in Chinese men with non-obstructive azoospermia who underwent testis biopsy

Keywords: CDK2; Male infertility; Non-obstructive azoospermia; Single-nucleotide polymorphisms;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2018 سفارش ترجمه

Astragaloside IV inhibits Angiotensin II-stimulated proliferation of rat vascular smooth muscle cells via the regulation of CDK2 activity

Keywords: Astragaloside IV; Angiotensin II; CDK2; Cdc25; VSMCs; Atherosclerosis;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2018 سفارش ترجمه

Discovery of novel CDK inhibitors via scaffold hopping from CAN508

Keywords: Pyrazolo[3,4-b]pyridine; Scaffold hopping; CAN508; CDK2; CDK9; Selectivity;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

MicroRNA-204-5p regulates 3T3-L1 preadipocyte proliferation, apoptosis and differentiation

Keywords: C/EBPα; CCAAT/enhancer-binding proteins; PPAR-γ; peroxisome proliferator activated receptor-γ coactivator; AP2; adipocyte fatty-acid binding protein 2; CDK4; cyclin dependent kinase 4; CDK2; cyclin dependent kinase 2; CDK5; cyclin dependent kinase 5; p

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

MicroRNA-143a-3p modulates preadipocyte proliferation and differentiation by targeting MAPK7

Keywords: aP2; adipocytefatty acid-binding protein; p21; cyclin-dependent kinase inhibitor 1; CDK2; cyclin-dependent kinase 2; Cyclin B; cell cycle protein B; Cyclin E; cell cycle protein E; CDK3; cyclin-dependent kinases 3; CDK4; cyclin-dependent kinases 4; C/EBPÎ

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Sirtuin7 has an oncogenic potential via promoting the growth of cholangiocarcinoma cells

Keywords: SIRT7; sirtuin7; HCC; hepatocellular carcinoma; CCA; cholangiocarcinoma; TCGA; The Cancer Genome Atlas; TNM; tumor-node-metastasis; CDK2; cyclin dependent kinase 2; NAD+; nicotinamide adenine dinucleotide; H3K18Ac; acetylated lysine 18 of histone H3; HDAC

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

LPS promotes HBO1 stability via USP25 to modulate inflammatory gene transcription in THP-1 cells

Keywords: HBO1; histone acetyltransferase binding to origin recognition complex 1; UPS25; ubiquitin specific peptidase 25; LPS; lipopolysaccharide; Cdt1; Chromatin Licensing And DNA Replication Factor 1; HDAC11; histone deacetylase 11; MCM; Minichromosome Maintenan

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

The cyclin-dependent kinase 2 (CDK2) mediates hematopoiesis through G1-to-S transition in Chinese mitten crab Eriocheir sinensis

Keywords: Eriocheir sinensis; Innate immunity; CDK2; Cell cycle; Hematopoiesis;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor

Keywords: Nicotinic acetylcholine receptor; Ion channel; Allosteric modulation; Virtual screening; 5-HT; 5-hydroxytryptamine; DB04763; 1-N-(4-sulfamoylphenethyl)-2,4,6-trimethylpyridinium tetrafluoroborate; AUC; area under the curve; CAII; carbonic anhydrase II; CD

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair

Keywords: CDK4/6; cyclin-dependent kinases 4 and 6; CDK2; cyclin-dependent kinase 2; iCDK4/6; inhibitor of CDK4/6; LEE011; inhibitor of CDK4/6, ribociclib, Kisqali; PD0332991; inhibitor of CDK4/6, palbociclib, Imbrance; NU6140; cyclin-dependent kinase 2 (CDK2) inhi

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Progesterone arrested cell cycle progression through progesterone receptor isoform A in pancreatic neuroendocrine neoplasm

Keywords: Pan-NEN; pancreatic neuroendocrine neoplasm; PR; progesterone receptor; PRA; PR isoform A; PRB; PR isoform B; CCNA2; cyclin A2; CCNB1; cyclin B1; CDK1; cyclin-dependent kinase 1; CDK2; cyclin-dependent kinase 2; WHO; World Health Organization; Neuroendocr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Design, synthesis and molecular modeling study of certain 4-Methylbenzenesulfonamides with CDK2 inhibitory activity as anticancer and radio-sensitizing agents

Keywords: 2-Aminopyridine; Tyrphostin AG17 analogs; 4-methylbenzenesulfonamide; CDK2; Cytotoxic; γ-radiation;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Role of miRNAs in cell signaling of cancer associated fibroblasts

Keywords: ATG; autophagy related; CAF; cancer associated fibroblasts; CCL; C-C motif chemokine ligand; CDK2; cyclin-dependentkinase 2; CXCL; chemokine(C-X-C motif) ligand; DRAM; damage-regulated autophagy modulator; ECM; extracellular matrix; EMT; epithelialto mese

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Low-functional programming of the CREB/BDNF/TrkB pathway mediates cognitive impairment in male offspring after prenatal dexamethasone exposure

Keywords: Akt; protein kinase B; Bax; Bcl-2 associated x protein; Bcl-2; B-cell lymphoma 2; BDNF; brain-derived neurotrophic factor; CaMKII; calmodulin-dependent protein kinase II; Caspase-3; cysteine aspartic protease 3; CDK2; cyclin-dependent kinase-2; CDC42; cel

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Effect of dioscin on promoting liver regeneration via activating Notch1/Jagged1 signal pathway

Keywords: Dioscin; Hepatocyte proliferation; γ-secretase; Liver regeneration; Notch1/Jagged1 signal pathway; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BrdU; 5-bromo-2-deoxy-uridine; CDK2; cyclin D-cyclin dependent kinase 2; CDK4; cyclin D-cyc

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

Nesfatin-1 functions as a switch for phenotype transformation and proliferation of VSMCs in hypertensive vascular remodeling

Keywords: α-SMA; α-smooth muscle actin; BCA; Bicinchoninic acid; CCK-8; Cell counting kit-8; CDK2; cyclin dependent kinase 2; DAPI; 4′,6-diamidino-2-phenylindole; DBP; diastolic blood pressure; DMEM; Dulbecco's modified Eagle's medium; DHE; dhydroethidium; EdU;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Suppression of Akt-mediated HDAC3 expression and CDK2 T39 phosphorylation by a bichalcone analog contributes to S phase retardation of cancer cells

Keywords: Bichalcone analog; CDK2; Cyclin A; HDAC3; S phase arrest;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Polyglutamine expansion diseases: More than simple repeats

Keywords: Neurodegenerative disease; Polyglutamine protein; Aggregation modulation; Post-translational modification; Molecular partner; Ataxin-3; APR; aggregation-prone region; αB-c; AlphaB-crystallin; AR; androgen receptor; Atx1; ataxin-1; Atx3; ataxin-3; Atn1; a

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Supervised machine learning techniques to predict binding affinity. A study for cyclin-dependent kinase 2

Keywords: Bioinformatics; CDK2; Kinase; Drug design; Docking; Machine learning;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

MicroRNA-27a-3p affects estradiol and androgen imbalance by targeting Creb1 in the granulosa cells in mouse polycytic ovary syndrome model

Keywords: miRNA; microRNA; miR-27-3p; microRNA-27a-3p; mGC; mouse granulosa cell; E2; estradiol; GC; granulosa cell; Creb1; cyclic AMP response element (CRE)-binding protein 1; Cyp19a1; cytochrome P450 family 19 subfamily A polypeptide 1; DHT; dihydrotestosterone;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Targeting kinase signaling pathways with constrained peptide scaffolds

Keywords: AKAP; A-kinase anchoring protein; Akt; protein kinase B; ALL; acute lymphoblastic leukemia; CBG; cyclin binding groove; CDK2; cyclin dependent kinase 2; CKII; casein kinase II; CKIIα; casein kinase II subunit alpha; CKIIβ; casein kinase II subunit beta;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Trisubstituted purine inhibitors of PDGFRα and their antileukemic activity in the human eosinophilic cell line EOL-1

Keywords: PDGFRα; platelet derived growth factor receptor alpha; CDK2; cyclin-dependent kinase 2; TK; tyrosine kinase; MAPK; mitogen-activated protein kinase; STAT; signal transducers and activators of transcription;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors

Keywords: CDK2; CDK5; Cancer; Dinaciclib; Kinase; Cyclobutylpurine;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Pyrrolizines: Design, synthesis, anticancer evaluation and investigation of the potential mechanism of action

Keywords: ALK1; activin receptor-like kinase; CDCl3; deuterated chloroform; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; DSV; discovery studio visualizer; DYRK3; dual specificity tyrosine phosphorylation-regulated kinase; CDK2; cyclin-depende

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

In silico study of porphyrin-anthraquinone hybrids as CDK2 inhibitor

Keywords: Molecular docking; Molecular dynamics simulation; MM-PBSA; CDK2; Porphyrin; Cancer;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

The role of C/EBPβ phosphorylation in modulating membrane phospholipids repairing in LPS-induced human lung/bronchial epithelial cells

Keywords: ALI; acute lung injury; ARDS; acute respiratory distress syndrome; PLA2; Phospholipase A2; CCSP; clara cell secretory protein; LPS; lipopolysaccharide; C/EBP β; CCAAT/enhancer binding protein β; SARS; severe acute respiratory syndrome; MOI; multiplicity

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

G2/M cell cycle arrest on HT-29 cancer cells and toxicity assessment of triphenylphosphanegold(I) carbonimidothioates, Ph3PAu[SC(OR) = NPh], R = Me, Et, and iPr, during zebrafish development

Keywords: Annexin V-FITC; Recombinant annexin V conjugated to fluorescein isothiocyanate; APAF-1; Apoptotic protease activating factor 1; ATR; Ataxia telangiectasia and Rad3-related; Bax; Apoptosis regulator; Bcl-2; B-cell lymphoma 2; BIRC-5; Baculoviral inhibitor

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal

Keywords: CAR; constitutive androstane receptor; CDK2; cyclin-dependent kinase 2; ChIP assay; chromatin immunoprecipitation assay; CYP; cytochrome P450; FOXO1; forkhead box protein O1; PCK1; phosphoenolpyruvate carboxykinase 1; PPARα; peroxisome proliferator-activ

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2017 سفارش ترجمه

A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties

Keywords: Rohitukine; Cdk2; Cdk9; Chromatography-free isolation; Dysoxylum binectariferum; Physicochemical properties

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2

Keywords: CRC; colorectal cancer; miRNA; microRNA; MTS; (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium); GAB1; GRB2-associated binding protein 1; SHC1; SRC homology 2 domain containing 1; GRB2; growth factor receptor-bound

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Structure-based design of benzo[e]isoindole-1,3-dione derivatives as selective GSK-3β inhibitors to activate Wnt/β-catenin pathway

Keywords: GSK-3β; Inhibitor; Wnt/β-catenin pathway; Neurodegenerative diseases; CDK2;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

CDK2 phosphorylation regulates the protein stability of KLF10 by interfering with binding of the E3 ligase SIAH1

Keywords: KLF10; TGF-β1; CDK2; Cell cycle; Phosphorylation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

miR-200c-SUMOylated KLF4 feedback loop acts as a switch in transcriptional programs that control VSMC proliferation

Keywords: ATRA; all-trans retinoic acid; cdk2; cyclin-dependent kinase 2; HASMC; human aortic smooth muscle cell; HDAC2; histone deacetylase 2; KLF; Krüppel-like factor; LSD1; lysine-specific demethylase 1; miR; microRNA; NCoR; nuclear receptor corepressor; p21; p

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies

Keywords: Coumarins; Anticancer; Synthesis; Targets; SAR; IC50; ARI; aromatase inhibitor; CAM; choriallanotoic membrane; CDC; cell cycle division protein; CDK2; cyclin dependent kinase 2; CDKN1A; cyclin-dependent kinase inhibitor 1A; CYP; cytochromes P450; DDIT4; D

دانلود رایگان متن کامل مقاله ISI 72 صفحه سال انتشار : 2015 سفارش ترجمه

Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor

Keywords: Kinases; Tumor; CDK2; Modulator; High throughput screening;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

The cell cycle profiling-risk score based on CDK1 and 2 predicts early recurrence in node-negative, hormone receptor-positive breast cancer treated with endocrine therapy

Keywords: Breast cancer; CDK1; CDK2; Prognosis; Tumor growth speed;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

TPPII, MYBBP1A and CDK2 form a protein-protein interaction network

Keywords: TPPII; MYBBP1A; CDK2; Cell cycle; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

The cyclin dependent kinase inhibitor (R)-roscovitine mediates selective suppression of alloreactive human T cells but preserves pathogen-specific and leukemia-specific effectors

Keywords: T cells; Graft versus host disease; Cdk2; T regulatory cells;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Activation of Src family tyrosine kinases by ferric ions

Keywords: CCK; cholecystokinin; CDK2; cyclin-dependent kinase 2; DMEM; Dulbecco's Modified Eagle Medium; HBS; HEPES-buffered saline; SFK; Src-family tyrosine kinases; Calcium; Kinase; Ferric; Iron; Phosphotyrosine;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

p27 is regulated independently of Skp2 in the absence of Cdk2

Keywords: Cyclin-dependent kinase; Knockout mice; Cdk2; Skp2; p27;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Myostatin knockout using zinc-finger nucleases promotes proliferation of ovine primary satellite cells in vitro

Keywords: Satellite cells; Myostatin; Gene expression; Mutant; Proliferation; PSC; primary satellite cell; TGF-β; transforming growth factor β; CDK2; cyclin-dependent kinase 2; p21; cyclin-dependent kinase inhibitor 1; DMEM; Dulbecco's modified eagle medium; FBS;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه