کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10158343 | 1666522 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MicroRNA-143a-3p modulates preadipocyte proliferation and differentiation by targeting MAPK7
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کلمات کلیدی
P21Cyclin BCDK3ELOVL6MAPK7CDK4CDK2DGATLPLCyclin EGLUT4AP2stearoyl-CoA desaturaseFABP4PPARγACSSCDacyl-CoA synthetase - Acyl-CoA SynthetaseC/EBPα - C / EBPαAdipogenesis - آدیپوژنزfatty acid synthase - اسید چرب سنتازcyclin-dependent kinase 2 - سیکلین وابسته به کیناز 2Fasn - فسادLipoprotein lipase - لیپو پروتئین لیپازObesity - مرض چاقیcyclin-dependent kinase inhibitor 1 - مهارکننده کیناز وابسته به سیکلین 1Glucose transporter type 4 - نوع حمل گلوکز 4CCAAT/enhancer binding protein alpha - پروتئین آلفای اتصال دهنده تقویت کننده CCAAT / تقویت کنندهperoxisome proliferator activated receptor γ - گیرنده پروتئینزا پراکسیوم فعال γ
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Adipogenesis plays a key role in increasing fat mass, which is a main characteristic for obesity, and involves preadipocyte proliferation and differentiation. Recently, more and more evidences suggested that microRNAs (miRNAs) is an important member of the regulatory network of adipogenesis. In this study, miR-143a-3p was highly expressed in adipose tissues of obese mice, and was up-regulated at the middle and last stage of 3T3-L1 adipocyte differentiation. Using mouse 3T3-L1 cells line, which is an ideal model in vitro for the study of adipogenesis, we observed that overexpression of miR-143a-3p inhibited the preadipocyte proliferation, and enhanced the preadipocyte differentiation. In contrast, the inhibition of miR-143a-3p expression promoted the preadipocyte proliferation, and inhibited the preadipocyte differentiation. Further analysis suggested that miR-143a-3p mediating preadipocyte differentiation might be involved in fatty acid metabolism. In addition, we found that miR-143-3p and PPARγ, an activator of miR-143a-3p transcription, could regulate each other. Compared with miR-143a-3p, MAPK7 played an opposite role in the proliferation and differentiation of adipocyte. Further analysis indicated that MAPK7 is a target gene of miR-143a-3p in 3T3-L1 cells, and inhibition of MAPK7 recede the effect of miR-143a-3p on preadipocyte proliferation and differentiation. Taken together, these results indicated that as a regulator of PPARγ, miR-143a-3p play an important role in adipogenesis via regulating MAPK7 and fatty acid.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 108, December 2018, Pages 531-539
Journal: Biomedicine & Pharmacotherapy - Volume 108, December 2018, Pages 531-539
نویسندگان
Peiwen Zhang, Jingjing Du, Linghui Wang, Lili Niu, Ye Zhao, Guoqing Tang, Yanzhi Jiang, Surong Shuai, Lin Bai, Xuewi Li, Jinyong Wang, Shunhua Zhang, Li Zhu,