Keywords: 4- Shogaol (PubChem CID: 9794897); 6- Shogaol (PubChem CID: 5281794); Apigenin (PubChem CID: 5280443); Berberine (PubChem CID: 2353); Bergamottin (PubChem CID: 5471349); Caffeic acid (PubChem CID: 689043)Capsaicin (PubChem CID: 1548943); Cardamonin (PubCh
مقالات ISI (ترجمه نشده)
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Keywords: Anticancer activity; Apoptosis; DNA repair; Glioblastoma; Seaweed compounds; Temozolomide; AIC; 5-aminoimidazole-4-carboxamide; Akt; Protein kinase B (PKB); AP site; apurinic/apyrimidinic site; AP-1; activator protein-1; APE-1; AP endonuclease; Bax; Bcl-2
Keywords: CDK4; cyclin-dependent kinase4; CNS; central nervous system; DMEM; Dulbecco's modified essential medium; EDTA; ethylenediaminetetraacetic acid; EdU; 5-erhynyl-2â²-deoxyuridine; FBS; fetal bovine serum; FITC; fluorescein isothiocyanate; GFAP; glial fibr
Keywords: DEGs; The differentially expressed genes; CAV3; caveolin 3; CDK4; cyclin-dependent kinase 4; GEO; Expression Omnibus; NCBI; National Center of Biotechnology Information; PPI; protein-protein interaction; EWS-ATF; EWS RNA-binding protein 1-activating trans
Keywords: genetics; genetic syndromes; inherited cancer risk; melanoma; oncogenes; skin cancer; tumor suppressor; ACD; adrenocortical dysplasia homologue; BAP1; BRCA1-associated protein-1 (ubiquitin carboxy-terminal hydrolase); CDKN2A; cyclin-dependent kinase inhib
Keywords: Sarcoma; Liposarcoma; Myxoid liposarcoma; Pleomorphic liposarcoma; CDK4; MDM2; FUS-CHOP; Trabectedin;
Keywords: Human muscle cell models; Immortalization; Myotonic dystrophy type 1; Cyclin D1; TERT; CDK4; ASOs;
Keywords: CDK4; CDKN2A; familial melanoma syndromes; FAMMM; melanoma genetics; mixed cancer syndromes;
Keywords: Cell cycle; Metabolism; Glycolysis; Cdk4; E2F1 transcription factor; Glucose;
Keywords: α-TOS; α-tocopheryl succinate; BAP1; BRCA1 associated protein-1; BRCA1; breast cancer susceptibility gene 1; CDK4; cyclin-dependent kinase 4; CEA; carcinoembryonic antigen; CSC(s); cancer stem(-like) cell(s); CTGF; connective tissue growth factor (CCN2)
Keywords: 5-hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosine; ADAM23; ADAM metallopeptidase domain 23; ADAMTS9; ADAM metallopeptidase with thrombospondin type 1 motif, 9; ARID1A; AT rich interactive domain 1A (SWI-like); AML; Acute myelocytic leukemia; ATBF1; A
Keywords: MDM2; CDK4; amplification; lipoma; liposarcoma
Association of the 16q24.3 region gene variants rs1805007 and rs4785763 with heightened risk of melanoma in Latvian population
Keywords: ACD; adrenocortical dysplasia protein homolog gene; AFG3L1P; AFG3-like matrix AAA peptidase subunit 1 of the pseudogene; BAP1; BRCA1 associated protein-1 gene; BRAF; serine/threonine-protein kinase B-Raf; CDK4; cyclin-dependent kinase 4; CDK10; cyclin-dep
Decreased local and systemic levels of sFRP3 protein in osteosarcoma patients
Keywords: sFRP3; Secreted Frizzled Related Protein 3; ELISA; enzyme linked immunosorbent assay; IgG; immunoglobulin; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; CDK4; cyclin-dependent kinase 4; Frzb; sFRP3; Wnt; Osteosarcoma;
MicroRNA-204-5p regulates 3T3-L1 preadipocyte proliferation, apoptosis and differentiation
Keywords: C/EBPα; CCAAT/enhancer-binding proteins; PPAR-γ; peroxisome proliferator activated receptor-γ coactivator; AP2; adipocyte fatty-acid binding protein 2; CDK4; cyclin dependent kinase 4; CDK2; cyclin dependent kinase 2; CDK5; cyclin dependent kinase 5; p
Oncogene RPA1 promotes proliferation of hepatocellular carcinoma via CDK4/Cyclin-D pathway
Keywords: RPA1; Hepatocellular carcinoma; Proliferation; Cell cycle; CDK4; Cyclin-D;
Metal- and redox homeostasis in prostate cancer with vitamin D3 supplementation
Keywords: Al; aluminium; ALT; alanine transaminase; AP-1; activated protein-1; AR; androgen receptor; AST; aspartate transaminase; B; boron; Ba; barium; BMI; body mass index; Ca; calcium; CDK4; cyclin dependent kinase; CEA; carcynoembrionic antigene; Chol; choles
Functions and mechanisms of microRNA-31 in human cancers
Keywords: 3â²-UTRs3â²; -untranslated regions; ADC; Adenocarcinoma; BC; Breast cancer; BER; base excision repair; CDK4; cyclin-dependent kinase 4; CRC; Colorectal cancer; CRT; chemo-radiation therapy; C-TAD; COOH terminal transactivation domain; DHR1; dihydrorhoda
MicroRNA-143a-3p modulates preadipocyte proliferation and differentiation by targeting MAPK7
Keywords: aP2; adipocytefatty acid-binding protein; p21; cyclin-dependent kinase inhibitor 1; CDK2; cyclin-dependent kinase 2; Cyclin B; cell cycle protein B; Cyclin E; cell cycle protein E; CDK3; cyclin-dependent kinases 3; CDK4; cyclin-dependent kinases 4; C/EBPÎ
Hyperoside and let-7a-5p synergistically inhibits lung cancer cell proliferation via inducing G1/S phase arrest
Keywords: SCLC; small-cell lung cancer; NSCLC; non-small-cell lung cancer; miRNA; microRNA; 3â²UTR; 3â²untranslated region; 5â²UTR; 5â²untranslated region; CDS; coding sequence; CDK6; cyclin-dependent kinase 6; CDK4; cyclin-dependent kinase 4; CCND1; cyclin D1;
E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes
Keywords: Gluconeogenesis; E2F1; Liver metabolism; Hyperglycemia; Diabetes; Cell cycle regulators; PCK1; Phosphoenolpyruvate carboxykinase 1; G6PC; glucose-6-phosphatase G6PC; PTT; Pyruvate tolerance test; CDK4; cyclin-cyclin-dependent kinase 4; PKA; protein kina
Novel circular RNA, hsa_circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma via the miR-198/CDK4 axis
Keywords: Circular RNA; Malignant melanoma; has_circ_0025039; Sponge; miR-198; CDK4;
Bioactive fraction of Rhodiola algida against chronic hypoxia-induced pulmonary arterial hypertension and its anti-proliferation mechanism in rats
Keywords: Arbutin (Pubchem CID: 440936); Gallic acid (Pubchem CID: 370); Salidroside (Pubchem CID: 159278); Tyrosol (Pubchem CID: 10393); Caffeic acid (Pubchem CID: 689043); p-Coumaric acid (Pubchem CID: 637542); Ferulic acid (Pubchem CID: 445858); Catechin (Pubche
A selective cyclin-dependent kinase 4, 6 dual inhibitor, Ribociclib (LEE011) inhibits cell proliferation and induces apoptosis in aggressive thyroid cancer
Keywords: Thyroid cancer; LEE011; Retinoblastoma protein (RB); CDK4; CDK6;
Lower miR-340 expression predicts poor prognosis of non-small cell lung cancer and promotes cell proliferation by targeting CDK4
Keywords: miRs; microRNAs; qRT-PCR; quantitative real-time PCR; 3â²-UTR; 3â²-untranslated region; NSCLC; non-small cell lung cancer; FBS; fetal bovine serum; DMEM; Dulbecco's modified Eagle medium; MircroRNA; Non-small cell lung cancer; miR-340; CDK4; Cell prolif
Dynamic regulation of mRNA and miRNA associated with the developmental stages of skin pigmentation in Japanese ornamental carp
Keywords: DEGs; differentially expressed genes; DEMs; differentially expressed miRNAs; dph; days post hatching; mc1r; melanocortin 1 receptor; mitf; microphthalmia-associated transcription factor; tyr; tyrosinase; tyrp1; tyrosinase related protein 1; dct; dopachrom
Expression and therapeutic implications of cyclin-dependent kinase 4 (CDK4) in osteosarcoma
Keywords: CDK4; cyclin-dependent kinase 4; RNAi; RNA interference; siRNA; small interfering RNA; Rb; retinoblastoma; TMA; tissues microarray; Osteosarcoma; Cyclin-dependent kinase 4; Palbociclib; Rb; Cell cycle;
The influence of peroxisome proliferator-activated receptor γ (PPARγ) ligands on cancer cell tumorigenicity
Keywords: Cancer cells; PPARγ agonist; PPARγ antagonist; Therapeutic agents; Tumorigenicity; ACC; Acetyl-CoA carboxylase; AKR1B10; Alde-keto reductase 1B10; Alpha-ESA; Alpha-eleostreac acid; ACLY; ATP citrate lyase; BADGE; Bisphenol-A-diglycidyl-etter; CSCs; Canc
Effect of dioscin on promoting liver regeneration via activating Notch1/Jagged1 signal pathway
Keywords: Dioscin; Hepatocyte proliferation; γ-secretase; Liver regeneration; Notch1/Jagged1 signal pathway; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BrdU; 5-bromo-2-deoxy-uridine; CDK2; cyclin D-cyclin dependent kinase 2; CDK4; cyclin D-cyc
Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry
Keywords: Well-differentiated/dedifferentiated liposarcoma; Differential diagnosis; p16; MDM2; CDK4; Immunohistochemistry; Fluorescence in situ hybridization;
miR-26a and miR-26b inhibit esophageal squamous cancer cell proliferation through suppression of c-MYC pathway
Keywords: ESCC; esophageal squamous cell carcinoma; miRNA; microRNA; MYCBP; MYC binding protein; UTR; untranslated-region; COSMIC; the catalogue of somatic mutation in cancer; siRNA; small interfering RNA; CCND1; cyclin D1; CDK4; cyclin-dependent kinase 4; MTA1; me
MicroRNA-27a-3p affects estradiol and androgen imbalance by targeting Creb1 in the granulosa cells in mouse polycytic ovary syndrome model
Keywords: miRNA; microRNA; miR-27-3p; microRNA-27a-3p; mGC; mouse granulosa cell; E2; estradiol; GC; granulosa cell; Creb1; cyclic AMP response element (CRE)-binding protein 1; Cyp19a1; cytochrome P450 family 19 subfamily A polypeptide 1; DHT; dihydrotestosterone;
Activation of PPARγ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms
Keywords: Pulmonary arterial smooth muscle cell; HDAC1; PPARγ; miR-124; CDK4;
Major triterpenoids in Chinese hawthorn “Crataegus pinnatifida” and their effects on cell proliferation and apoptosis induction in MDA-MB-231 cancer cells
Keywords: Crataegus pinnatifida; MDA-MB-231; Ursolic acid; Apoptosis; Cell cycle; Semi-preparative HPLC; CC50; half maximal cytotoxicity concentration; EC50; half maximal effect concentration; UA; ursolic acid; CA; corosolic acid; OA; oleanolic acid; MA; maslinic a
Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells
Keywords: SIRT1; Sirtunin; AURKB; Aurora B kinase; CRC; Colorectal cancer; BMFC; Butea monosperma flower compounds; mRNA; Messenger ribonucleic acid GSK Glycogen synthase kinase; WHO; World health organization; HDAC; Histone deacetylase; CSCs; Cancer stem cells; Bm
Selective ATP competitive leads of CDK4: Discovery by 3D-QSAR pharmacophore mapping and molecular docking approach
Keywords: CDK4; ATP competitive inhibitors; 3D-QSAR pharmacophore; Virtual screening; Docking; ADME;
G2/M cell cycle arrest on HT-29 cancer cells and toxicity assessment of triphenylphosphanegold(I) carbonimidothioates, Ph3PAu[SC(OR)Â =Â NPh], RÂ =Â Me, Et, and iPr, during zebrafish development
Keywords: Annexin V-FITC; Recombinant annexin V conjugated to fluorescein isothiocyanate; APAF-1; Apoptotic protease activating factor 1; ATR; Ataxia telangiectasia and Rad3-related; Bax; Apoptosis regulator; Bcl-2; B-cell lymphoma 2; BIRC-5; Baculoviral inhibitor
Treatment Rationale and Study Design for the JUNIPER Study: A Randomized Phase III Study of Abemaciclib With Best Supportive Care Versus Erlotinib With Best Supportive Care in Patients With Stage IV Non-Small-Cell Lung Cancer With a Detectable KRAS Mutati
Keywords: Biomarkers; CDK4; CDK6; Cyclin-dependent kinase; LY2835219;
Secoisolariciresinol diglucoside rich extract of L. usitatissimum prevents diabetic colon cancer through inhibition of CDK4
Keywords: Secoisolariciresinol diglucoside; L. usitatissimum; Colon cancer associated with type 2 diabetes mellitus; CDK4; DMH
Research paperFerulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro
Keywords: FA; Ferulic acid; CCND1; Cyclin D1; CDK4; Cyclin Dependent Kinase 4; CDK6; Cyclin Dependent Kinase 6; RB; Retinablastoma gene; BCL-XL; B-cell lymphoma-extra large; BID; BH3 Interacting Domain Death Agonist; DR4; HLA-DR4; DR5; Death receptor 5; FADD; Fas-A
ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma
Keywords: Melanoma; Therapeutic efficacy; ANRIL; INK4A; INK4B; lncRNAs; long non-coding RNAs; siRNA; small interfering RNA; PCR; polymerase chain reaction; RPE; retinal pigment epithelial; GFP; green fluorescence protein; NST; melanoma-neural system tumor; CDK4;
Prediction of clinical outcomes using the pyrolysis, gas chromatography, and differential mobility spectrometry (Py-GC-DMS) system
Keywords: bcl-1; b-cell lymphoma-isoform 1; CDK4; Cyclin dependent kinase 4; CDKN2A; cyclin dependent kinase inhibitor 2A; MIB-1; mindbomb 1; SOX-11; sry-related HMG box; IL-2Rα; interleukin-2 receptor alpha; IL-8; interleukin-8; MIP-1β; macrophage inflammatory p
PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells
Keywords: API5; apoptosis inhibitor 5; ARF1; ADP ribosylation factor 3; BCA; bicinchoninic acid; BBC3/PUMA; BCL2 binding component 3; BIRC5; baculoviral IAP (inhibitor of apoptosis) repeat containing 5; CDC25A; cell division cycle 25A; CDK4; cyclin-dependent kinase
Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells
Keywords: AP; Acute pancreatitis; BACH1; BTB and CNC homology 1, basic leucine zipper transcription factor 1; BACH2; BTB and CNC homology 1, basic leucine zipper transcription factor 2; CARD9; Caspase recruitment domain family, member 9; CDK4; Cyclin-dependent kina
Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease
Keywords: cdk4; cyclin D3; NAFLD; p300; C/EBP; hepatic steatosis
New insight into the role of metabolic reprogramming in melanoma cells harboring BRAF mutations
Keywords: ATP; adenosine triphosphate; BRAF; serine/threonine-protein kinase B-Raf; cAMP; cyclic adenosine monophosphate; CDK4; cyclin-dependent kinases 4; CREB; cAMP response element binding protein; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxi
MDM2 and CDK4 expression in periosteal osteosarcoma
Keywords: Perisoteal osteosarcoma; Bone; MDM2; CDK4; Immunohistochemistry
MicroRNA in prostate cancer
Keywords: DGCR8; Digeorge syndrome chromosomal region 8; CCNDs; cyclin Ds; CDK4; cyclin-dependent kinase 4; CDK6; cyclin-dependent kinase 6; E2F; E2 transcription factor; E2F2; E2 transcription factor 2; IGF1R; insulin-like growth factor 1 receptor; ELK1; ELK1 memb
Natural plant flavonoid apigenin directly disrupts Hsp90/Cdc37 complex and inhibits pancreatic cancer cell growth and migration
Keywords: Apigenin; Heat shock protein 90; Cell division cycle protein 37; SRL-PFAC; Pancreatic cancer; Apigenin (PubChem CID: 5280443); Galangin (PubChem CID: 5281616); Baicalein (PubChem CID: 5281605); Genistein (PubChem CID: 5280961); Naringenin (PubChem CID: 93
δ-Tocotrienol treatment is more effective against hypoxic tumor cells than normoxic cells: potential implications for cancer therapy
Keywords: Akt; protein kinase B; CDK4; cyclin-dependent kinase 4; DLD-1; human colorectal adenocarcinoma cell line; H&E; hematoxylin and eosin; HIF-1α; hypoxia inducible factor-1α; NIH; National Institutes of Health; PBS; phosphate-buffered saline; PECAM-1; plate