کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8644851 | 1569770 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dynamic regulation of mRNA and miRNA associated with the developmental stages of skin pigmentation in Japanese ornamental carp
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کلمات کلیدی
foxd3CSF1TRPM7FPKMKLF4DcTMc1rTYRP1colony stimulating factor-1Pax7DPHSF3B1Forkhead box D3SLC45A2Tyrosinase related protein 1Kit ligand aDifferentially expressed miRNAsKif5bKrüppel like factor 4SRY-Box 2RNA-seqCDK4MITFDEMSFDRSox2Oct4TPMDEGsCRFdopachrome tautomerase - تاتومراز dopachromeRNA sequencing - ترتیب RNATyr - تیرTyrosinase - تیروزیناز paired box 7 - جعبه زوج 7Skin pigmentation - رنگدانه پوستdays post hatching - روز پس از اخاذیXanthine dehydrogenase/oxidase - زانتین دهیدروژناز / اکسیدازStar - ستارهCyclin Dependent Kinase 4 - سیکلین وابسته به کیناز 4corticotropin-releasing factor - عامل تخریب کورتیکوتروپینMicrophthalmia-associated transcription factor - فاکتور رونویسی مرتبط با میکرو فتالمیFragments per kilobase of transcript per million mapped reads - قطعه در هر کیلو بایت رونویسی در هر میلیون نقشه برداری شده استtranscript per million - متن در هر میلیونBIM - مدلسازی اطلاعات ساختمانGenetic regulation - مقررات ژنتیکیfalse discovery rate - میزان کشف کاذبSteroidogenic acute regulatory protein - پروتئین حاکم استروئیدوژنیک حادperilipin - پریلیپینDifferentially expressed genes - ژن های متفاوت بیان شده استPLIN - کاملMelanocortin 1 receptor - گیرنده ملانوکورتین 1scavenger receptor class B member 1 - گیرنده گیرنده گروه B عضو 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The Japanese ornamental carp (Cyprinus carpio var. Koi) is famous for multifarious colors and patterns, making it commonly culture and trade across the world. Although functional genes and inheritance of color traits have been commonly studied, seldom attentions were focused on the genetic regulation during the developmental process of pigmentation. To better understand the mechanism of skin color development, we observed the morphogenesis of pigment cells during the post-embryonic stages and analysed the temporal expression pattern of mRNAs/miRNAs profiles in four distinct developmental stages. 59 and 103 differentially expressed genes/miRNAs (DEGs/DEMs) associated with pigmentation and skin were identified, including pax7, mitf, tyr, tyrp1, etc., and the highest DEGs were detected at 11â¯days post hatching (dph). In addition, the functional characteristics of mRNAs/miRNAs associated with pteridine and carotenoid pathway were also examined. Furthermore, 65 miRNA-mRNA interaction pairs related to pigmentation, pteridines and carotenoids metabolism were detected between different stages. Interestingly, the largest pairs appeared in the transition from 11â¯dph to 48â¯dph, which had the similar trend with DEGs further manifesting the importance of 11â¯dph. This study produced a comprehensive programme of DEGs/DEMs during color development, which will provide resources to understand the regulation mechanism in color formation. The understanding of genetic basis in color formation might promote the production and breeding of the Koi carp.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 666, 5 August 2018, Pages 32-43
Journal: Gene - Volume 666, 5 August 2018, Pages 32-43
نویسندگان
Xue Tian, Xiaolei Pang, Liangyan Wang, Mengrong Li, Chuanju Dong, Xiao Ma, Lei Wang, Dongying Song, Jianxin Feng, Peng Xu, Xuejun Li,