کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2524547 1557960 2016 5 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Assessment of erythropoietin for treatment of anemia in chronic kidney failure- ESRD patients
ترجمه فارسی عنوان
ارزیابی اریتروپویتین برای درمان کم خونی در نارسایی مزمن کلیه - بیماران مبتلا به ESRD
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موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

Background and objectiveCurrently there is an inadequate data regarding effective management of anemia in chronic kidney disease (CKD) patients who are on dialysis. In CKD patients’ anemia mainly develops from decreased renal synthesis of erythropoietin (EPO) and iron deficiency. Our current study focused to effective management of anemia in CKD patients’.Study designProspective observational case series study.MethodsEligible patients were assigned to three study groups according to initial hemoglobin level i.e. Group I having Hb level below 11 g/dL, Group II with Hb level of 11–13 g/dL, and Group III with Hb level more than 13 g/dL. Intravenous dosing of ESA’s calculated according to the range of 150–300 IU or equivalent microgram quantity per kilogram body weight was administered to patients in divided doses per week; alone or in combination with iron supplements.ResultsStudy population (n = 163; 100%), of which 124 subjects (76%) patients were treated with erythropoietin and iron supplements; rest of 39 (24%) patients were treated with only erythropoietin. The estimation of hemoglobin content revealed Group I (98 patients) Hb were increased significantly from 9.0 ± 1.2 g/dl at baseline to 10.9 ± 1.7 g/dl. No significant changes in Group II and Group III were observed.ConclusionsStudy suggests use of erythropoietin along with iron for treatment of renal failure associated anemia is more beneficial for CKD patients having low Hb. Also study conclude the use of lower than normal dose (150–300 IU) of ESA is appropriate when hemoglobin reaches 11 g/dl in hemodialysis patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 82, August 2016, Pages 44–48
نویسندگان
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