کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7802368 | 1501159 | 2012 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
⺠A series of 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidines were synthesized. ⺠The relative stereochemistry of target compounds were confirmed by NOESY NMR spectra. ⺠Most of the synthesized compounds showed significant to moderate cytotoxic activity. ⺠Compound 15f was 1.7- to 66.5-folds more active than GDC-0941 against three cell lines. ⺠3D-QSAR analysis employed by CoMFA and CoMSIA model on H460 cell line was investigated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 57, November 2012, Pages 162-175
Journal: European Journal of Medicinal Chemistry - Volume 57, November 2012, Pages 162-175
نویسندگان
Wufu Zhu, Yajing Liu, Xin Zhai, Xiao Wang, Yan Zhu, Di Wu, Hongyu Zhou, Ping Gong, Yanfang Zhao,