کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7802368 1501159 2012 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents
چکیده انگلیسی
► A series of 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidines were synthesized. ► The relative stereochemistry of target compounds were confirmed by NOESY NMR spectra. ► Most of the synthesized compounds showed significant to moderate cytotoxic activity. ► Compound 15f was 1.7- to 66.5-folds more active than GDC-0941 against three cell lines. ► 3D-QSAR analysis employed by CoMFA and CoMSIA model on H460 cell line was investigated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 57, November 2012, Pages 162-175
نویسندگان
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