Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents

► A series of pyrazolo[4,3-c]cinnoline derivatives were synthesized. ► Characterized by IR, 1H NMR, 13C NMR, and DART-MASS technique. ► Anti-inflammatory, ulcerogenic, lipid peroxidation, COX-2 inhibition and antibacterial studies were performed. ► Compounds 4d and 4l showed excellent protection against inflammation. ► Compound 4b emerged as a potential dual anti-inflammatory-antibacterial agent.