Design of new arylamino-2-ethane-1,1-diyl- and benzoxazole-2-methylene-bisphosphonates vs cytotoxicity and chronic inflammation diseases. From hydrophobicity prediction to synthesis and biological evaluation

► 2-hydroxyphenyl-β-amino- and benzoxazole-methylenebisphosphonates. ► Hydrophobicity prediction. ► Potency of bisphosphonates in comparison with relevant acid-counterparts. ► Anticancer and antichronic inflammatory agents. ► Specific anti-breast cancer agents.