Synthesis, spectral characterization and biological evaluation of a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl)propan-2-yl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines

► A novel series of triazolothiadiazines were synthesized. ► Compounds were screened for their cytotoxicity using MTT assay. ► Compounds also tested for their anthelmintic & antimicrobial activities. ► 7j was the most promising cytotoxic agent with IC50 value of 10.54 μM in MCF-7 cells.