Synthesis of novel pyrrolyl-indomethacin derivatives

► Synthesis of the two novel esters of IDMC and one ester of reduced IDMC was performed. ► IDMC was covalently bound by using a spacer chain to the pyrrole in the 3-position. ► The innovative monomers were tested in order to study their cytotoxicity using primary calvarial osteoblasts as a cell model. ► Monomers (Py-IDMC) exhibited no cytotoxic effects.