Iridoid glucosides from Nyctanthes arbortristis result in increased reactive oxygen species and cellular redox homeostasis imbalance in Leishmania parasite

► Iridoid glucosides from Nyctanthes arbortristis result in increased reactive oxygen species. ► These compounds show significant effect on redox homeostasis and high leishmanicidal activity. ► Parasitic death follows apoptotic mechanism. ► These compounds are safe on human cell lines.