Keywords: تریپانوتیونی ردوکتاز; Click chemistry; 1,2,3-Triazole; Amino acid tail; Anti-leishmanial; Docking studies; Trypanothione reductase;
مقالات ISI تریپانوتیونی ردوکتاز (ترجمه نشده)
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Keywords: تریپانوتیونی ردوکتاز; GLO2; glyoxalase II or hydroxyacylglutathione hydrolase; Grx1; monothiol glutaredoxin 1; Grx3; monothiol glutaredoxin 3; MG; methylglyoxal; TXN; tryparedoxin; TXN-Px; tryparedoxin peroxidase; PDO; persulfide dioxygenase; PSTK; phosphoseryl-tRNASec kinase;
Keywords: تریپانوتیونی ردوکتاز; Chagas disease; Pharmacoinformatics; Molecular docking; Enzyme-inhibitor complex; TryR; trypanothione reductase; T. cruzi; Trypanosoma cruzi; QUM; quinacrine mustard; ADMET; absorption, distribution, metabolism distribution and toxicity; BBB; blood brain
Keywords: تریپانوتیونی ردوکتاز; Imipramine; Molecular dynamics; Trypanothione reductase; Visceral leishmaniasis; ADMET;
Keywords: تریپانوتیونی ردوکتاز; CJai; flux control coefficient; CumOOH; cumene hydroperoxide; GPxA; tryparedoxin-dependent glutathione peroxidase A; MCA; Metabolic Control Analysis; TryR; trypanothione reductase; TryS; trypanothione synthetase; T(SH)2; trypanothione; TXN; tryparedoxin;
Keywords: تریپانوتیونی ردوکتاز; TR; trypanothione reductase; GR; glutathione reductase; DBS; dibenzosuberyl, 10,11-dihydro-5H-dibenzo[a,d]cycloheptenyl; DBA; 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepinyl; T(SH)2; trypanothione dithiol; T(S)2; trypanothione disulfide; BR; binding region
Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic
Keywords: تریپانوتیونی ردوکتاز; Trx; thioredoxin; TrxR; thioredoxin reductase; Sec; selenocysteine; ROS; reactive oxygen species; RNR; ribonucleotide reductase; GSH; glutathione; GR; glutathione reductase; Grx; glutaredoxin; GPx; glutathione peroxidase; Msr; methionine-R-sulfoxide reduc
Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability
Keywords: تریپانوتیونی ردوکتاز; Stapled peptides; Protein-protein interactions; Trypanothione reductase; Leishmania infantum; Cell-penetrating peptides; CD; circular dichroism; CPP; cell-penetrating peptide; ELISA; Enzyme-Linked ImmunoSorbent Assay; FCS; fetal calf serum; FITC; fluoresc
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase
Keywords: تریپانوتیونی ردوکتاز; Chalcone; Drug discovery; Leishmaniasis; Natural products; Neglected tropical disease; Trypanothione reductase;
Bistacrines as potential antitrypanosomal agents
Keywords: تریپانوتیونی ردوکتاز; Bistacrine; Antitrypanosomal drugs; Rhodesain; Trypanothione reductase;
First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity#
Keywords: تریپانوتیونی ردوکتاز; Peptides; Helix stabilization; Protein-protein interactions; Trypanothione reductase; Leishmania infantum; Cell-penetrating peptides; CPP; cell-penetrating peptide; DSSP; define secondary structure of proteins algorithm; ELISA; Enzyme-Linked ImmunoSorbent
Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates
Keywords: تریپانوتیونی ردوکتاز; Antikinetoplastids; Trypanosoma brucei; Leishmania donovani; Polyamines; Benzotriazole; Trypanothione reductase;
Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress
Keywords: تریپانوتیونی ردوکتاز; Amp B; Amphotericin B; APx; ascorbate peroxidase; CS; cysteine synthase; DTNB; 5,5`-dithiobis-(2-nitrobenzoic acid); FBS; fetal bovine serum; γ-GCS; γ-glutamylcysteine synthetase; GSH; glutathione; GST; glutathione S-transferase; LdCS; Leishmania donova
Novel β-carboline-quinazolinone hybrids disrupt Leishmania donovani redox homeostasis and show promising antileishmanial activity
Keywords: تریپانوتیونی ردوکتاز; Leishmania donovani; Trypanothione reductase; β-Carboline-quinazolinone hybrid; Atomic Force Microscopy; In-silico docking; Drug development;
Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides
Keywords: تریپانوتیونی ردوکتاز; α/β-Peptides; Foldamers; Proteolysis; Protein-protein interactions; Trypanothione reductase; Leishmania infantum; CPP; cell-penetrating peptide; DSSP; define secondary structure of proteins algorithm; ELISA; Enzyme-Linked ImmunoSorbent Assay; 5-FITC; fl
Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity
Keywords: تریپانوتیونی ردوکتاز; Trypanosoma cruzi; Chagas disease; Natural neolignans; Diaryl-tetrahydrofurans; Diarylfurans; Trypanothione reductase; 2D-QSAR; FDIRGEKGHSJYDA-UHFFFAOYSA-N; ZQHOSYBLSYGUBK-UHFFFAOYSA-N; SWHPMLPSMGMATL-UHFFFAOYSA-N; ZKTQNVXLUVNDFA-UHFFFAOYSA-N; VQVATVPHIAZ
Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis
Keywords: تریپانوتیونی ردوکتاز; Natural product analogues; Drug design; Isoxazole; Trypanosoma cruzi; Leishmania amazonensis; Trypanothione reductase; %GI; percentage of growth inhibition; AB; amphotericin B; BZN; benznidazol; logP; partition coefficient octanol/water; MW; microwave; ND
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity
Keywords: تریپانوتیونی ردوکتاز; Coumarins; Crassiflorone; Glyceraldehyde-3-phosphate dehydrogenase; Leishmaniasis; Natural products; Quinones; Trypanocidal activity; Trypanosomiasis; Trypanothione reductase; ITBVMLGZYFLEOG-UHFFFAOYSA-N; ZKZUWCSTPJSZDC-UHFFFAOYSA-N; ANVXOWUHEHGKLJ-UHFFFA
Synthesis and evaluation against Leishmania amazonensis of novel pyrazolo[3,4-d]pyridazinone-N-acylhydrazone-(bi)thiophene hybrids
Keywords: تریپانوتیونی ردوکتاز; Antileishmanial activity; Pyrazolo-pyridazinone; N-acylhydrazone; Thiophene; Trypanothione reductase;
Thiol redox biology of trypanosomatids and potential targets for chemotherapy
Keywords: تریپانوتیونی ردوکتاز; Trypanothione reductase; Trypanothione synthetase; Inhibitor; Drug; Trypanosoma; Leishmania;
Leishmania infantum trypanothione reductase is a promiscuous enzyme carrying an NADPH:O2 oxidoreductase activity shared by glutathione reductase
Keywords: تریپانوتیونی ردوکتاز; Trypanothione reductase; Sulfenic acid; Electron transfer; O2 reduction; Glutathione reductase; Promiscuous enzymes;
Evaluation of a diospyrin derivative as antileishmanial agent and potential modulator of ornithine decarboxylase of Leishmania donovani
Keywords: تریپانوتیونی ردوکتاز; Diospyrin; Naphthoquinonoid compounds; Antileishmanial agent; Leishmania donovani; Trypanothione reductase; Ornithine decarboxylase;
Further evidence of the trypanocidal action of eupomatenoid-5: Confirmation of involvement of reactive oxygen species and mitochondria owing to a reduction in trypanothione reductase activity
Keywords: تریپانوتیونی ردوکتاز; Trypanosoma cruzi; Eupomatenoid-5; Trypanothione reductase; ROS; Mitochondria; Cell death; Free radicals;
Trypanothione: A unique bis-glutathionyl derivative in trypanosomatids
Keywords: تریپانوتیونی ردوکتاز; 1-C-Grx; monothiol glutaredoxin; 2-C-Grx; dithiol glutaredoxin; CBS; cystathionine-β-synthase; CGL; cystathionine-γ-lyase; CHAP; cysteine histidine-dependent amidohydrolases/peptidases (protein domain); CS; cysteine synthase; DMPO; 5,5â²-dimethyl-l-pyr
Redox metabolism in Trypanosoma cruzi: Functional characterization of tryparedoxins revisited
Keywords: تریپانوتیونی ردوکتاز; Grx; glutaredoxin; GR; glutathione reductase; TR; trypanothione reductase; T(SH)2; trypanothione; TS2; trypanothione disulfide; GSSG; glutathione disulfide; GSH; reduced glutathione; TXNPx; 2-Cys-peroxiredoxin-type tryparedoxin peroxidase; GPxI; glutathio
The trypanothione system and its implications in the therapy of trypanosomatid diseases
Keywords: تریپانوتیونی ردوکتاز; Trypanothione synthetase; Trypanothione reductase; Tryparedoxin; Tryparedoxin peroxidases; Target validation; Drugability
Investigation of trypanothione reductase inhibitory activity by 1,3,4-thiadiazolium-2-aminide derivatives and molecular docking studies
Keywords: تریپانوتیونی ردوکتاز; Trypanothione reductase; Mesoionic compounds; Leishmania sp.; Trypanosoma cruzi;
Iridoid glucosides from Nyctanthes arbortristis result in increased reactive oxygen species and cellular redox homeostasis imbalance in Leishmania parasite
Keywords: تریپانوتیونی ردوکتاز; Nyctanthes arbortristis; Iridoids glucosides; Antileishmanial; Reactive oxygen species; Redox homeostasis; Drug development; TR; trypanothione reductase; NADPH; reduced nicotinamide adenine dinucleotide phosphate; DTNB; 5-5â²-dithio-bis(2-nitrobenzoic ac
A fast virtual screening approach to identify structurally diverse inhibitors of trypanothione reductase
Keywords: تریپانوتیونی ردوکتاز; Chagas disease; Trypanothione reductase; Virtual screening; Similarity search; Shape similarity;
A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage
Keywords: تریپانوتیونی ردوکتاز; T. brucei; Trypanosoma brucei; L. major; Leishmania major; wt; wild-type; Px; non-selenium glutathione peroxidase-type tryparedoxin peroxidase; TXNPx; 2-Cys-peroxiredoxin-type tryparedoxin peroxidase; TR; trypanothione reductase; Tpx; tryparedoxin; T(SH)2
Leishmania-macrophage interactions: Insights into the redox biology
Keywords: تریپانوتیونی ردوکتاز; 6PGDH; 6-phosphogluconate dehydrogenase; AMB; amphotericin-B; ASC; ascorbate; BH4; 5,6,7,8-tetrahydrobiopterin; CaM; calmodulin; CL; cutaneous leishmaniasis; DETA; diethylenetriamine; eEF1B; eukaryotic elongation factor 1B; eNOS or NOS3; endothelial nitri
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi
Keywords: تریپانوتیونی ردوکتاز; TryR; trypanothione reductase; T(S)2; trypanothione disulphide; DTNB; 5,5â²-dithio-bis(2-nitrobenzoic acid); HAT; human African trypanosomiasis; Trypanothione metabolism; Trypanosome; Thiol; Enzymology; Drug discovery;
Preparative enzymatic synthesis of trypanothione and trypanothione analogues
Keywords: تریپانوتیونی ردوکتاز; Trypanothione; Trypanothione synthetase; Trypanothione reductase; Crithidia fasciculata; Glutathionylspermidine; Drug development;
Molecular docking of a series of peptidomimetics in the trypanothione binding site of T. cruzi Trypanothione Reductase
Keywords: تریپانوتیونی ردوکتاز; CD, Chagas’ disease; TR, Trypanothione Reductase; GSSG, human glutathione; N1,N8-Bis(glutathionyl)spermidine, trypanothione or TS2Peptidomimetic; Docking; Trypanothione Reductase; FlexX; Chagas’ disease
Leishmania donovani trypanothione reductase: Role of urea and guanidine hydrochloride in modulation of functional and structural properties
Keywords: تریپانوتیونی ردوکتاز; Leishmania donovani; Trypanothione reductase; Unfolding; Intermediate; CD; Fluorescence; Molten globule
Assaying phenothiazine derivatives as trypanothione reductase and glutathione reductase inhibitors by theoretical docking and Molecular Dynamics studies
Keywords: تریپانوتیونی ردوکتاز; Chagas’ disease; Phenothiazines; Trypanothione reductase; Binding affinity; Theoretical docking; Molecular Dynamics
The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors
Keywords: تریپانوتیونی ردوکتاز; Trypanosomatid; Trypanothione reductase; Enzymatic inhibition; Linear competitive inhibitors
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle
Keywords: تریپانوتیونی ردوکتاز; Benzofuroxan; Trypanosoma cruzi; ESR; Cruzipain; Trypanothione reductase
High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity
Keywords: تریپانوتیونی ردوکتاز; Trypanothione reductase; High-throughput screening; Trypanosomiasis
Interaction energies of nitrofurans with trypanothione reductase and glutathione reductase studied by molecular docking
Keywords: تریپانوتیونی ردوکتاز; Nitrofurans; Trypanothione reductase; Binding affinity; Docking; Chagas' disease;
Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity
Keywords: تریپانوتیونی ردوکتاز; Polyamine; Trypanothione; Trypanothione reductase; Trypanosome; Trypanosomiasis; Inhibitor; Antiparasitic; Guanidine; Biguanide
Naegleria fowleri: A free-living highly pathogenic amoeba contains trypanothione/trypanothione reductase and glutathione/glutathione reductase systems
Keywords: تریپانوتیونی ردوکتاز; Drug target; Naegleria fowleri; Cysteine; Glutathione; Trypanothione; Glutathione reductase; Trypanothione reductase; T(S)2, trypanothione disulphide; Gspd, glutathionyl-spermidine; MALDI-TOF, matrix assisted laser-desorption ionization-time-of-flight; mB
Expression, purification, and characterization of Leishmania donovani trypanothione reductase in Escherichia coli
Keywords: تریپانوتیونی ردوکتاز; Leishmania donovani; Trypanothione reductase; Escherichia coli; Heterologous expression;
Mechanism and structure–activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase
Keywords: تریپانوتیونی ردوکتاز; Trypanothione reductase; Parallel synthesis; Mechanism of action; Structure–activity relationships