Seven-membered cycloplatinated complexes as a new family of anticancer agents. X-ray characterization and preliminary biological studies

► Seven-membered cyclometallated Pt(II) compounds as a new class of potential anticancer drugs. ► Non-planar arrangement of these compounds deduced from molecular structures. ► Remarkable antiproliferative activity in the human lung carcinoma, breast and colon cancer cell lines. ► These compounds modify the DNA tertiary structure, in a similar way than cisplatin.