Is chemical synthetic accessibility computationally predictable for drug and lead-like molecules? A comparative assessment between medicinal and computational chemists

► 11 Chemists estimated synthetic accessibility of each other's lead-like molecules. ► Good agreement obtained between average chemist scores and SYLVIA software. ► Selection of compounds should be done by several chemists instead of individuals. ► Evaluation of synthetic accessibility for drugs since 1970. ► SYLVIA can be used efficiently to rank and prioritize virtual compound libraries.