Synthesis, biological assay in vitro and molecular docking studies of new Schiff base derivatives as potential urease inhibitors

► Urease inhibitors have gained potential as novel drugs for the treatment of ulcer. ► We designed and synthesized a new series of Schiff based derivatives. ► They were most potent and low molecular weight inhibitors of the urease. ► Binding mode of Schiff base compounds was same for Jack bean and Helicobacter pylori urease.