Diastereoselective synthesis and bioactivity of long-chain anti-2-amino-3-alkanols

► An improved diastereoselective synthesis of anti-2-amino-3-alkanols is reported. ► Seven long-chain anti-2-amino-3-alkanol natural products have been synthesized. ► In vitro study in human glioblastoma cell line SHG-44 undertook. ► These compounds induced cell death and inhibited cell proliferation.