Synthesis and anticonvulsant activity of some new thiazolo[3,2-a][1,3]diazepine, benzo[d]thiazolo[5,2-a][12,6]diazepine and benzo[d]oxazolo[5,2-a][12,6]diazepine analogues

► Thiazolo-diazepine, benzothiazolo-diazepine and benzooxazolo-diazepine analogues were synthesized. ► Anticonvulsant activity of the new compounds was evaluated. ► Compounds 12, 20, and 24 showed 100% protection against PTZ-induced seizures. ► Compounds 12, 20, and 24 proved to act as GABAA receptor agonist.