Green synthesis and antimicrobial evaluation of some new trifluoromethyl-substituted hexahydropyrimidines by grinding

► Atom-efficient, solvent-free synthesis of trifluoromethyl hexahydropyrimidines. ► Economical and environmentally benign one pot three component synthesis by grinding. ► This protocol proved to be more effective than classical Biginelli reaction. ► Nine compounds exhibited remarkable biological activity compared with tetracycline.