Synthesis and structure-activity relationship studies of 4-arylthiosemicarbazides as topoisomerase IV inhibitors with Gram-positive antibacterial activity. Search for molecular basis of antibacterial activity of thiosemicarbazides

► Thiosemicarbazides as potential antibacterials and topoisomerase IV inhibitors. ► H-bonds important for ligand-enzyme interaction. ► Electronic properties of molecule important for ligand-enzyme interaction.