Studying synergism of methyl linked cyclohexyl thiophenes with triazole: Synthesis and their cdk5/p25 inhibition activity

► Tractable small molecules for the treatment of Alzheimers disorder. ► “Hit” from a newer chemotype was identified, which is under further development. ► A chemotype was recognized on which additional chemical modifications are being carried out. ► MORE technology was used through-out experimental which provides a 'Green Route' for synthesis.